Our findings revealed a positive correlation between the expression levels of LAG3 and IFNG (R = 0.76, p < 0.001), PRF1 (R = 0.75, p < 0.001), FASLG (R = 0.75, p < 0.001), GZMH (R = 0.74, p < 0.001), NKG7 (R = 0.74, p < 0.001), and PDCD1 (R = 0.73, P < 0 0.001) in pan-cancer tissues (Fig. 5B). The gene discussed is PRF1; the disease is cancer.