AKT1 and cancer: A commonly tested flavonoid, quercetin, induces its anticancer activity by modulating VEGF, apoptosis, PI3K/Akt/mTOR, and Wnt/β- catenin signaling pathways, in addition to inhibiting the inflammatory enzymes of the cyclooxygenase (COX) pathway and other inflammatory mediators, thus reducing the risk of cancer [89, 90].