Similarly, early insulin resistance, defined as the slow progressive need for higher fasting insulin to maintain normal fasting glucose concentrations, can be seen years or decades before the appearance of increased fasting glucose, glucose intolerance, and elevated glycated hemoglobin (HbA1c) that are characteristic of the insulin resistance–prediabetes–type 2 diabetes spectrum [1]. This evidence concerns the gene INS and type 2 diabetes mellitus.