Consistent with P. chabaudi infection causing an increase in INa density of CA1 pyramidal neurons through the TNFR1–JAK2–FGF14–Nav1.6 signaling network, which we posit occurs through TNF inducing increased FGF14/Nav1.6 complex assembly leading to increased trafficking of Nav1.6 channels to the plasma membrane, the infection correspondingly increased the intrinsic excitability of hippocampal neurons. This evidence concerns the gene JAK2 and infection.