Given that the voltage-dependences of activation and inactivation of Nav1.6-mediated INa were not affected by the infection or sensitive to the pharmacological manipulations tested, the effect of TNF on INa through the TNFR1–JAK2–FGF14–Nav1.6 signaling network is likely mediated by increased trafficking of channels to the plasma membrane. This evidence concerns the gene JAK2 and infection.