This protective effect of genetic silencing of FGF14 in CA1 neurons on body temperature, however, was not generalized, as weight loss from cachexia was not different between the two groups of infected mice (Fig. 6F), indicating that silencing FGF14 in the CA1 region of the hippocampus in the context of eCM leads to a specific effect on thermoregulation. The gene discussed is FGF14; the disease is Cachexia.