Although the exact mechanism by which knocking down FGF14 in CA1 prevents hypothermia induced by P. chabaudi and reduces parasitemia throughout the course of infection is unclear, a likely candidate is through modulation of hippocampal-hypothalamic connectivity, the latter of which is centrally involved in the hypothalamic–pituitary–adrenal (HPA axis) [96] and serves as a canonical regulator of thermoregulation [97, 98]. This evidence concerns the gene FGF14 and infection.