TNF and infection: Consistent with P. chabaudi infection causing an increase in INa density of CA1 pyramidal neurons through the TNFR1–JAK2–FGF14–Nav1.6 signaling network, which we posit occurs through TNF inducing increased FGF14/Nav1.6 complex assembly leading to increased trafficking of Nav1.6 channels to the plasma membrane, the infection correspondingly increased the intrinsic excitability of hippocampal neurons.