We established a prognostic risk model for GBM using 18 (PDHA1, GLS, ATP7B, PDHB, LIAS, GCSH, SLC31A1, FDX1, ATP7A, NLRP3, DBT, MTF1, DLAT, DLD, DLST, NFE2L2, LIPT1 and CDKN2A) cuproptosis-related genes by Cox and Lasso regression analysis. This evidence concerns the gene DLD and glioblastoma.