reveals the interaction of these cuproptosis-related genes.Conversely, DLD, NLRP3, MTF1, DBT, SLC31A1, and PDHB displayed broad amplification, particularly DLD (Fig. S1). Nevertheless, the observed CNV alterations do not align consistently with the mRNA expression patterns observed in GBM and normal samples. This evidence concerns the gene PDHB and glioblastoma.