Further examination through the use of a volcano plot (Fig. 2B) and boxplot (Fig. 2C) demonstrated that CDKN2A, FDX1, LIPT1, SLC31A1, DLST, NFE2L2, and ATP7A displayed significant upregulation, whereas GLS, PDHA1, and ATP7B exhibited marked downregulation in GBM. The gene discussed is ATP7B; the disease is glioblastoma.