Compared with the IVIG-sensitive group, the duration of hospitalization, ALT, AST, GLB, r-GT, IgG, PCT, and ESR were elevated and RBC, HGB, ALB, A/G, and CK were significantly lower in the IVIG-resistant Kawasaki disease group (P < 0.05). The gene discussed is ESR1; the disease is Kawasaki disease.