In the study of Østergaard and colleagues, MCC950 was administered at a total weekly dose of 15 mg/kg i.p. in non-diabetic and diabetic apolipoprotein E knockout mice with established diabetic kidney disease, resulting in increased renal injury and macrophage infiltration in association with increased cellular oxidative stress, as well as increased mesangial expansion and glomerulosclerosis via upregulation of inflammatory and fibrotic markers [27]. This evidence concerns the gene APOE and glomerulosclerosis.