According to a recent study, MCC950 inhibits the NLRP3 inflammasome, which prevents acute renal failure by increasing hypoxia-inducible factor 1 and BCL2/adenovirus E1B interacting protein-mediated mitophagy, which lessens the effects of iohexol-induced apoptosis and renal injury [26]. Here, NLRP3 is linked to acute kidney injury.