HAVCR2 and malignant colon neoplasm: A number of studies have also shown that the downregulation of TIM-3 is closely related to metastasis and poor prognosis in prostate and colon cancer (Wu et al. 2017; Sun et al. 2017) and inhibits the proliferation and invasion of renal clear cell carcinoma and HeLa cells (Yuan et al. 2014; Cao et al. 2016).