Aspartate 314 (D314) of tau is another site for cleavage by caspase-2; this process could mislocalize tau to dendritic spines, which can facilitate the mislocalization of tau proteins, leading to reduced postsynaptic AMPA receptors and reduced excitatory neurotransmission [120], thereby affecting cognitive and synaptic function in animal and cellular models of tauopathies and reversibly damaging memory in animal models [121]. The gene discussed is MAPT; the disease is tauopathy.