At that time, they found that some NH2-terminal fragments, such as 26–44 tau and 26–230 tau, induced N-methyl-D-aspartate receptor (NMDAR)-mediated cell death [183], and 26–230 tau was also found by others in cellular and animal models of AD, so they named this fragment NH2-26–230 tau (aka NH2-tau) [184]. This evidence concerns the gene MAPT and Alzheimer disease.