ALKBH5 and Sepsis: Given the crucial role of neutrophil production in the host antibacterial defense, we investigated whether ALKBH5 might influence granulopoiesis in vivo by performing cecal ligation and puncture (CLP) to establish a well-recognized polymicrobial sepsis model with severe systemic infection that closely resembles clinical sepsis, on Alkbh5-deficient mice and their wild-type (WT) littermates.