CDH1 and neoplasm: To explore whether TCB-activated T cells infiltrate within organoids by binding to E-cadherin and whether T-cell exclusion within tumour organoids could be explained by its downregulation, we used an αE(CD103)β7-inhibitor cocktail comprising a recombinant human monoclonal antibody etrolizumab36 and an anti-integrin β7 monoclonal antibody37 to inhibit the CD103-E-cadherin interaction within TCB-treated co-cultures (Extended Data Fig. 2c).