What is consistent with KEGG analysis is that lysosome, mTOR signaling, Notch signaling pathway, ERBB signaling pathway, VEGF signaling pathway, P53 signaling pathway, MAPK signaling pathway, pathways in cancer, regulation of autophagy and cell cycle were significantly enriched in the low-LRRS group (Fig. 7E). The gene discussed is TP53; the disease is cancer.