CD4 and neoplasm: Furthermore, we used the CIBERSORT algorithm to verify the infiltration level of immune cells in TCGA cohort and found that the low-LRRS group shown a higher infiltration of a variety of anti-tumor immune cells, including B naive cells (p < 0.05), CD4+ T memory resting cells (p < 0.05), Monocytes (p < 0.05), and Mast resting cells (p < 0.05), while high-LRRS group showed a higher estimated proportion of tumor-promoting cell, Tregs (p < 0.01) (Fig. 9I).