ATP6V0E1 and type 2 diabetes mellitus: In nutshell, we identified seven hub genes (HIST2H2AA3, HIST2H2AA4, NFKBIA, SESN2, SMURF1, TGFβ1, TNRC6A) in T2DM vs. PC, six common hub genes (ATP6V0D1, ATP6V0C, ATP6V0E1, CTSD, CYBA, TGFβ1) in T2DM vs. LC and five common hub genes (ALYREF, CDKN2D, NGDN, THRAP3, UBE2M) in T2DM vs. BC, respectively (Fig. 3).