The 39 proteins significantly increased in DEP-treated ApoE−/− mice were subjected to IPA analysis (Table 3), revealing that the top five molecular and cellular functions in order of significance were ‘cell-to-cell signaling and interaction,’ ‘cellular function and maintenance,’ ‘cellular development,’ ‘cellular growth and proliferation,’ and ‘cell morphology.’ The two diseases and disorders most related were ‘inflammatory response’ and ‘cardiovascular disease,’ indicating that DEP exposure could cause CVDs in ApoE−/− mice. The gene discussed is APOE; the disease is cardiovascular disorder.