One striking negative correlation in the NR group was seen between TME PD-L1 positive cells (stromal region) and many systemic cytokines and chemokines known to be important for inducing an anti-tumor response via tissue migration and inflammation including IL-1a, IL-1b, IL-12p40, RANTES, SDF1a, TNF-a, TNF-b and others (Fig. 7 and Suppl. This evidence concerns the gene CXCL12 and neoplasm.