IL6 and obesity due to melanocortin 4 receptor deficiency: Adipokines, also known as adipocytokines, are cell-signalling molecules (cytokines) generated by adipose tissue that have an impact on the body's energy/metabolic state, inflammation, obesity, etc. Leptin, adiponectin, resistin, interleukin-6, and tumor necrosis factor are a few prominent adipokines12.