HAVCR2 and neoplasm: Nonetheless, the gene expression profiling is consistent with an active immune response including upregulation of markers of immune activation such as TIM-3 (HAVCR2) and CD70 (expressed on antigen-activated immune cells), STK10 (a marker of tumor-infiltrating immune cells) as well as genes associated with antigen-presenting cells (CD68, FPR1, FPR2, FCGR2A, TMEM176A, TMEM176b).