Additionally, reprocessing of our previously collated microarray data revealed that out of 11, eight genes of laminin family, including LAMA1, LAMA2, LAMA3, LAMA5, LAMB1, LAMB3, LAMC2 and LAMC3 were significantly upregulated in CCA tissues when compared with the adjacent noncancerous tissues, and one gene, LAMA4, was downregulated (Fig. 1d). This evidence concerns the gene LAMA3 and cholangiocarcinoma.