Mean FC of LAMA3B, LAMA5, LAMB3 and LAMC2 expression in CCA tissues compared to noncancerous counterpart were 3.5 (0.1–133 folds), 3.9 (0.3–216 folds), 9.2 (0.5–202 folds) and 37.7 (0.3–1,105 folds), respectively (Fig. 2b); however, there was no significant correlation between the expression levels and clinicopathology (Supplementary Table S1) as well as survival time of patients (Supplementary Fig. S1). Here, LAMC2 is linked to cholangiocarcinoma.