ABI1 and familial pancreatic carcinoma: To further investigate the biological role of RBFOX2-mediated ABI1 exon 9 skipping to promote pancreatic cancer progression, we induced ABI1 splice-switching in Panc1 cells using an ABI1 AON to mimic the ABI1 ∆PSI observed with RBFOX2 knockdown (Fig. 8a).