The transparency of the nematode enables easy visualization of fluorescent reporters, such that tagging the α-synuclein to GFP or YFP has shown that the resulting aggregates resemble the Lewy body-like inclusions in human PD and lead to increasing toxicity with age94,101, but has also enabled the identification of neuroprotective genes94,103 and compounds that affect α-synuclein aggregation101,104. This evidence concerns the gene SNCA and Parkinson disease.