CGAS and cancer: To further explore the detailed molecular mechanisms of cGAS inhibiting the LPS-induced inflammatory response in HBE cells, we further analyze transcriptional differences in RNA sequencing analysis and the data showed that the expression of 7686 genes in HBE cells were altered after cGAS knockdown (3850 upregulated and 3836 downregulated), and the top 50 upregulated genes mainly included cancer-related genes, some chemokines, and transcription factors.