Furthermore, we analyzed the breast cancer predisposition genes in each molecular subtype (Supplementary Fig. S4c–e), resulting in the characterization of ATM (OR, 2.91; 95% CI, 1.25–6.45) and PTEN (OR, 10.04; 95% CI, 1.44–111.08) as predisposition genes exclusively in the HR+/HER2– subtype (Supplementary Table S7). Here, PTEN is linked to breast cancer.