TSPO and Anxiety: Due to this feature, TSPO has beensuggested as a biomarker of neuroinflammation20 and the progression of these pathologies.21 Conversely, TSPO is downregulated in the brains of patients withpost-traumatic stress, anxiety, and obsessive-compulsive disorders22 and upon repeated stress, including noise exposure.23 Small synthetic TSPO ligands have been developedand biologically evaluated as potential tools for treating TSPO-relateddisorders, and TSPO has gained recognition as a marker and therapeutictarget of neuropsychiatric pathologies.