TSPO and myocardial infarction: In a more recent study, the possiblecardioprotective effects ofRo5-4864, alone or in the presence of the NO synthase (NOS) inhibitorN(ω)-nitro-l-arginine methyl ester (L-NAME), were evaluatedin a model of ISO-induced rat MI.131 Lowerlevels of circulating and myocardial markers of ischemic injurieswere measured in the Ro5-4864-treated group, which was partially preventedby L-NAME, thus suggesting that NO should be an important mediatorof the TSPO ligand action.131