As previously explained in section 4.1, Ro5-4864 can increase BayK8644-inducedmyocardial ischemia; in contrast, PK11195 has been shown to inhibitit.29 Both Ro5-4864 and PK111195 couldalso have a direct action on calcium channels, in addition to thatvia TSPO. This evidence concerns the gene TSPO and ischemia.