In the present report, an overview of the recent literatureevaluatingthe effects of TSPO ligands on cardiac pathophysiology is presented,together with the most representative examples of the few TSPO radioligandsstudied so far for diagnosing CDs, particularly atherosclerosis, myocarditis,large vessel vasculitis (LVV), and myocardial infarction (MI). This evidence concerns the gene TSPO and cerebral creatine deficiency syndrome.