Moreover, these interfrontal mesenchymal suture cells and cells of the osteogenic front normally express several growth factors that are known to promote keratinocyte migration or proliferation (including keratinocyte growth factor [Kgf/Fgf7], Igf1, Igf2, and Fgf10) (Figure 9A and Supplemental Figure 11A), suggesting that the structural midline skull/suture defects in Wnt1Cre+Kctd1fl/flKctd15fl/fl mice likely cause ACC as a consequence of reduced spatiotemporal expression of these keratinocyte-promoting growth factors at that site during development. This evidence concerns the gene IGF1 and adrenal cortex carcinoma.