KCTD1 and adrenal cortex carcinoma: Furthermore, we show that KCTD1 and KCTD15 control cranial neural crest cell (NCC) functions and that the combined loss of both KCTD1 and KCTD15 in NCCs results in ACC-like lesions of the midline scalp that are linked to midline cranial suture defects, establishing ACC as a neurocristopathy.