SIRT1 and neurodegenerative disease: Similarly, SIRT1 is a nicotinamide adenine dinucleotide-dependent histone deacetylase, which imparts a fundamental role in neuroprotection through abolishing multiple factors involved in neuronal death in neurodegenerative diseases, such as oxidative stress and neuroinflammation (Manjula et al. 2020; Zhang et al. 2020).