When ICD was induced in B16F10-OVA tumour cells maleimide-displaying CpG nanodepots (Mit-B 16F10-OVA-CpG-NPs) significantly upregulated the costimulatory molecules CD40 and CD86 as along with inflammatory cytokines (IL-12p70, IFN-β, TNF-α) which are associated with increased antigen presentation and T cell activation. Here, TNF is linked to neoplasm.