PLXDC1 (angiogenic marker gene) siRNA-incorporated chitosan NP coated with HA (HA-CH-NP/siRNA, size of 200 nm) reduced the tumour growth in epithelial ovarian cancer with ~ 2.1-fold increased binding of NP on cancer cells with significant reduction of PLXDC1 expression [43]. The gene discussed is PLXDC1; the disease is cancer.