TP53 and cancer: Silica NPs are mesoporous within a diameter range of 2–50 nm, and these mesoporous silica NPs (MSNP) are widely used for drug delivery, catalysis, adsorption, separation, etc. Two natural agents, curcumin and colchicine, were loaded on MSNPs, and efficacy was tested against several cancer cell lines, in vitro, (breast cancer cell MCF-7, colon carcinoma HCT-116 cells, lung cancer A-549 cells) where maximum efficacy was obtained against HCT-116 cells with an IC50 < 5 μg/ml showing apoptotic death with increased p53, caspase-3, and Bax expression, but inhibited Bcl-2 expression [85].