For instance, to predict survival outcome of PC patients, Xu N et al. (2018) analyzed 1417 DEGs by comparing expression profiling of PC and non-PC tissues, and then screened out 4 DEGs (HOXB5, GPC2, PGA5 and AMBN) through univariate and multivariate Cox regression analysis, which were significantly correlated with OS of PC patients [25]. This evidence concerns the gene GPC2 and pachyonychia congenita.