PTH and hypercalcemia disease: Remarkably, as reported for his sister, patient 2, this patient presented a decrease in the occurrence of hypo- and hypercalcemia, and a significant decrease in PTH requirements from 42.4 ± 0.7 μg/day to 21.2 ± 0.7 μg/day (p < 0.0001) suggesting a partial remission of hypoparathyroidism (Fig. 3D, E).