Pla also affects the FasL-dependent production of several inflammatory cytokines during pneumonic plague that is detrimental for the host against bacterial growth (Caulfield et al. 2014) Other interesting strategies directed toward Fas/FasL to avoid the induction of apoptosis through the extrinsic pathway are displayed by Mycobacterium tuberculosis, a pathogenic bacterium of the Mycobacteriaceae family and the causative agent of tuberculosis. This evidence concerns the gene FASLG and pneumonic plague.