These findings were replicated in the WCDT metastatic tumor cohort, where FASN gene expression was significantly higher in ETS fusion positive versus negative cases (P < 0.05; Fig. 4E) and mean FASN gene methylation by WGBS was concomitantly significantly lower in ETS fusion positive versus negative cases (P < 0.01; Fig. 4F). The gene discussed is FASN; the disease is metastatic neoplasm.