Mounting evidence shows the pyroptosis-related genes share an overlapping pathogenic effect which leads to the chronic inflammation and VSMCs remodeling in AAA, such as the Nod-like receptor family pyrin (NLRP) 3 [9, 10], the interleukin (IL)-1β [11] and caspase family [12]. The gene discussed is IL1B; the disease is triple-A syndrome.