The results of the data analysis showed that compared with that in normal lung tissue, the expression of LINC00665 in IPF lung tissues was obviously higher than that in normal healthy control lung tissues (p=0.000006, p<0.001) (Supplementary file Figure 1B), and the expression of XBP-1 in IPF lung tissue was significantly increased (Supplementary file Figure 1C, p=0.014). The gene discussed is XBP1; the disease is idiopathic pulmonary fibrosis.