Next, in the mice model of pulmonary fibrosis, we confirmed that CSE positively regulates LINC00665/XBP-1 to participate in the lung fibroblast-to-myofibroblast transition and that LINC00665 regulates XBP-1 by negatively regulating miR-214-3p. Here, LINC00665 is linked to pulmonary fibrosis.