In terms of cancer, our results indicate that P2-HNF4α is not oncogenic per se – the P2-HNF4α transcriptome shows only a partial overlap with HCC, key proliferation markers (Ki67 and PCNA) are not upregulated in α7HMZ livers and there is no evidence of hepatomegaly (Figures 1H, 7E, Supplementary Figures 1D,E). This evidence concerns the gene MKI67 and hepatocellular carcinoma.