HNF4A and hepatocellular carcinoma: In terms of cancer, our results indicate that P2-HNF4α is not oncogenic per se – the P2-HNF4α transcriptome shows only a partial overlap with HCC, key proliferation markers (Ki67 and PCNA) are not upregulated in α7HMZ livers and there is no evidence of hepatomegaly (Figures 1H, 7E, Supplementary Figures 1D,E).