Finally, several matrix metalloproteinases (Mmp14, Mmp15, Mmp19), which are linked to poor prognosis of liver or colorectal cancer patients (73–75), are also upregulated by P2-HNF4α (Supplementary Table 1) and dysregulation of genes involved in drug metabolism could impact treatment of liver cancer (Figure 3). The gene discussed is HNF4A; the disease is colorectal cancer.