It is universally known that aberrant reactivation of epithelial-mesenchymal transition (EMT) is correlated to malignant properties of tumor cells during cancer progression and metastasis [19], and thus, markers of EMT were investigated, which showed that improving LYPLAL1-DT expression enabled to curb EMT of TNBC cells and repressing LYPLAL1-DT expression had a contrary effect to EMT of TNBC cells (Fig. 3I and Fig. S5E). Here, LYPLAL1 is linked to cancer.