ASPH and breast cancer: According to Lin et al.’s report, aspartate β-hydroxylase (ASPH) promotes EV secretion in the MDA-MB-231 breast cancer cell line, and these EVs contain factors involved in invasion and metastasis, including active Notch receptors, JAGs, ADAM, and matrix metalloproteinase (MMP), thereby contributing to the promotion of breast cancer cell metastasis (Lin et al., 2019).