DLC1 and Familial prostate cancer: Similarly, in a report on prostate cancer, another type of cancer that frequently develops bone metastasis similar to breast cancer, miR-141-3p contained in EVs derived from MDA PCa 2b prostate cancer cells inhibits the expression of DLC1, a Rho GTPase-activating factor, as a target gene, promoting bone metastasis (Ye et al., 2017).