AHR and airway hyperresponsiveness: The airway hyperresponsiveness was reduced in OVA-induced asthma model with inhibition or loss of TRPV1 expression in vagus sensory neurons, but airway inflammation could not be decreased [26, 27], indicating that the function to regulate airway inflammation and AHR of vagus nerve is complex, which can regulate airway inflammation and AHR alone or at the same time.