SEMA3E and allergic asthma: Movassagh et al. [12] found that downregulation of Sema3E could promote the proliferation and contraction of airway smooth muscle cells, and increase airway collagen deposition and mucus production, eventually leading to increased airway responsiveness in dust mite sensitization of Sema3E-/- allergic asthma mouse model, while after Sema3E treatment, the airway hyperresponsiveness was significantly reduced [12], further elucidating the protective effect of Sema3E in asthma, which might become a new therapeutics for human asthma.