The airway hyperresponsiveness was reduced in OVA-induced asthma model with inhibition or loss of TRPV1 expression in vagus sensory neurons, but airway inflammation could not be decreased [26, 27], indicating that the function to regulate airway inflammation and AHR of vagus nerve is complex, which can regulate airway inflammation and AHR alone or at the same time. Here, TRPV1 is linked to airway hyperresponsiveness.