The proteins downregulated in CHL, in comparison to polyps, demonstrated enrichment in the KEGG pathway of bile secretion (padjusted = 0.039), which included ATP1B1, ABCC2, ABCB11, ABCB4, ABCB1, and ABCG8 (Figures 5D,E; Supplementary Table S6). This evidence concerns the gene ATP1B1 and classic Hodgkin lymphoma.