Additionally, the interleukin-17 (IL-17) signaling pathway (padjusted = 8.2E-06) was enriched in the upregulated protein in CHL, including MMP9, LCN2, S100A9, S100A8, MUC5AC, MUC5B, and MMP1. Here, S100A8 is linked to classic Hodgkin lymphoma.