The level of serum anti-CD47 antibody in PBC patients was significantly higher than that in the Control group [4437.50(3850.00, 10631.25) ng/L,3018.75(2443.75, 3475.00) ng/L; Z=-3.43, P=0.001, Figure 7)]. The gene discussed is CD47; the disease is primary biliary cholangitis.