Therefore, the present research clarified the expression of CD47/SIRPα on mononuclear cells in PBC patients, investigated the effect of serum inflammatory cytokines on the CD47 expression in PBC patients, analyzed potential autoantibodies against CD47 in PBC patients, and explored the role of CD47 and anti-CD47 antibody in the inflammatory response of PBC, provided laboratory basis for the study of the pathogenesis and targets for non-invasive diagnosis and treatment on PBC. Here, CD47 is linked to primary biliary cholangitis.