The CD47 expression level on CD14+ monocytes was higher than that on CD56+ NK cells, CD3+ T cells or CD19+ B cells in PBC patients (t=5.812, 6.573, 6.951, P<0.001, respectively), there were no significant difference in the CD47 expression levels among the CD3+ T cells, CD19+ B cells and CD56+ NK cells in PBC patients (P>0.05) (Figure 2A). The gene discussed is NCAM1; the disease is primary biliary cholangitis.