Anti-CD47 antibody enhanced the phagocytosis of macrophages by binding to the Fc receptor on the macrophages, which might destroy the interaction of CD47/SIRPα, increase the phagocytic activity of macrophages, lead to an aggravation of experimental autoimmune encephalomyelitis and autoimmune nephritis (33, 34). This evidence concerns the gene CD47 and experimental autoimmune encephalomyelitis.