The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), immunoglobulin M (IgM) and immunoglobulin A (IgA) in PBC patients were higher than those in the control group (P<0.05). The gene discussed is GPT; the disease is primary biliary cholangitis.