CXCL8 and acute myeloid leukemia: On the contrary, genes implicated in leukemogenesis (IL-6, CCL2, and CXCL8) (28–30) were significantly increased in AML-exposed BMSCs in both basal (IL-6, p=0.0055; CXCL2, p=0.0105; CXCL8, p=0.0201) and osteogenic conditions (IL-6, p=0.0005; CCL2, p=0.001; CXCL8, p=0.0205) (Figure 3B).