Analysis of expression of the osteoblast late markers BGLAP and SPP1 showed a strong downregulation in BMSCs co-cultured with HL-60 compared to control at day 21 of differentiation (BGLAP at day 21: p=0.0160; SPP1 at day 21: p=0.0242), suggesting an impairment in the capacity of BMSCs to differentiate into mature osteoblasts in the presence of AML cells (Figure 2B). This evidence concerns the gene SPP1 and acute myeloid leukemia.