BGLAP and acute myeloid leukemia: Analysis of expression of the osteoblast late markers BGLAP and SPP1 showed a strong downregulation in BMSCs co-cultured with HL-60 compared to control at day 21 of differentiation (BGLAP at day 21: p=0.0160; SPP1 at day 21: p=0.0242), suggesting an impairment in the capacity of BMSCs to differentiate into mature osteoblasts in the presence of AML cells (Figure 2B).