The immune microenvironment associated with these tumors includes the expression of high levels of vascular endothelial growth factor and other molecules conducive to tumor growth and invasivity, together with abundant tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) that play dual roles in driving and restraining TNBC development and progression (7). The gene discussed is VEGFA; the disease is neoplasm.