The following three most highly influential articles included ‘Selection of Bone Metastasis Seeds by Mesenchymal Signals within Primary Tumor Stroma’ by Zhang et al., ‘In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target’ by Wang and colleagues, and ‘A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging’ by Keren and colleagues (IF = 66.85; Table 3). The gene discussed is COP1; the disease is breast carcinoma.