In other studies using MCT to establish a rat model of pulmonary hypertension (PH), peroxiredoxin 6 (PRDX6) was found to regulate ferroptosis in PAECs through HMGB1 release and activation of the TLR4/NLRP3 inflammasome signaling pathway (179). This evidence concerns the gene HMGB1 and pulmonary hypertension.