TNF and allergic disease: •Common side effects included fevers in 19 patients diarrhea in 7 patients and allergic reactions in 3 patients which did not necessitate discontinuation of therapy•The beta-elimination half-life of MDX-H210 ranged from 4 to 8 hours at doses up to 20 mg/m2•Release of cytokines IL-6 G-CSF and TNF-α•Increasing human anti-BsAb after the third infusion•No objective clinical responses