CD8A and neoplasm: * Entrainment of the CTS, increased production of melatonin and lower cortisol release at night (82)* Anti-inflammatory and immunoregulatory effects (91)* Immune cell mobilisation to peripheral bloodstream, including PD-1 CD8+ T cells, which are vital for host tumour defence (88, 89)* Enrichment of gut microbiome (91)