RRM1 and mesothelioma: Other biomarkers are currently studied for their prognostic significance in mesothelioma, such as GLUT-1, COX-2, p27 (9),, CDKN2Adeletion (20), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) (19), and low RRM1 and ERCC1 (21), but these have not been explored in large-sampled studies to completely generalize their usage in clinical practice.