Previous studies revealed that in melanoma and colorectal carcinoma, CAFs could release C-X-C motif chemokine ligand 5 (CXCL5), which binds to the C-X-C motif chemokine receptor 2 (CXCR2) on cancer cells (Li et al., 2019). Here, CXCR2 is linked to colorectal carcinoma.