FEN1 and colorectal cancer: Variant-to-gene annotation (Table 1, Fig. 3B) revealed that only rs4246215 at 11q12.2 in FEN1 was associated with colorectal cancer susceptibility in both East Asian (OR = 0.92, 95% CI: 0.87–0.95, P = 1.46 × 10−6) and European (OR = 0.95, 95% CI: 0.92–0.98, P = 4.41 × 10−4) populations and reached genome-wide significance (OR = 0.94, 95% CI: 0.90–0.97, P = 4.70 × 10−9) without heterogeneity (Phet = 0.27, I2 = 0.20).