FEN1 and colorectal cancer: Interestingly, FEN1, one of 108 genes in the four selected pathways (specifically the DNA replication pathway), was significantly associated with colorectal cancer susceptibility in East Asian populations (PBonferroni = 0.025; Fig. 3A and Supplementary Table 2 [available online]), and was subsequently validated in European populations (P = 4.41 × 10−4; Supplementary Table 2).