CD4 and colorectal neoplasm: In addition, we found that rs4246215 decreased DNA replication activity in colorectal tumors but not in normal tissues (Fig. 5B) and dramatically influenced the proportions of five immune cells (i.e., basophils, CD4 Tem, eosinophils, mesangial cells, and Th2 cells; Fig. 5C and Supplementary Table 9 [available online]).