PDK1 and hepatocellular carcinoma: To confirm this result, we determined whether AKT interacted with STEAP4 in HCC cells with STEAP4 overexpression or knockdown, and AKT interaction with STEAP4 was reduced in Huh1 with STEAP4 overexpression compared to those expressing empty vector, but the interaction between AKT and PDK1 was reduced.