FFAR4 and Anxiety: Along with our previous findings showing that prolonged central GPR120 activation can inhibit anxiety in high-fat fed mice [12], our current results suggest that stimulating brain GPR120 with an agonist that crosses the blood brain barrier may offer a promising strategy for attenuating neuroimmune responses, sickness-like behaviors and mood perturbations via its capacity to restrain microglial reactivity and cytokine synthesis and release.