The present study set out to determine the GPR120 neural expression profile in mouse and human and NAc murine microglia; the capacity of GPR120 agonism to moderate acute proinflammatory responses in microglia, including NAc microglia, and the influence of central GPR120 agonism on anxiety- and sickness-like behaviors and neuroinflammatory indices in the NAc produced by acute systemic (LPS) and central (cytokines) inflammatory interventions. This evidence concerns the gene FFAR4 and Anxiety.