CGAS and autoimmune disease: In the same line of evidence, diseases in which cGAS/STING is constitutively activated and/or IFN-β level is elevated, including autoimmune diseases such as systemic lupus erythematosus [41, 42], autoinflammatory diseases such as STING-associated vasculopathy with onset in infancy [47], are also associated with high MPV and/or thrombotic risk.