G6PD and hepatocellular carcinoma: Moreover, the combination of regorafenib and 6AN decreased the colony formation (Fig. 3E) , cell viability (Figure S5B) and IC50 (Fig. 3D) of regorafenib in G6PD overexpressed cells of HCC, which demonstrated that 6AN removed the effect of G6PD overexpression on regorafenib resistance.