PPP is an alternative pathway of glucose catabolism, which is mainly regulated by glucose-6-phosphate dehydrogenase(G6PD), 6-phosphogluconate dehydrogenase(6PGD), transketolase (TKT), and transaldolase 1(TAL), etc. Metabolomic analysis suggested that PPP may be the most relevant pathway regulating regorafenib resistance in HCC, but its alteration was not validated. This evidence concerns the gene TALDO1 and hepatocellular carcinoma.